Isoquercitrin

Description

Of the various types of quercetin, the enzymatically modified form, Isoquercitrin (alpha-oligoglucosyl isoquercitrin), has been identified as having the greatest bioavailability. Quercetin, a flavonol found in various vegetables and herbal medicines, has considerable biological activity, possessing anti-cancer, anti-allergy and antioxidant effects. However, the use of quercetin has been limited by its insolubility in water and hence low oral bioavailability.

Isoquercitrin is derived from another flavonol, rutin, through natural enzymatic modification. As a result of modifications to its structure, Isoquercitrin EMIQ is, up to 12 hours after ingestion, 17 times more bioavailable and more concentrated in the blood, compared with simple dihydroquercetin. In vitro studies have shown that two enzymes, lactase and maltase-glucoamylase, play an important role in the rapid intestinal hydrolysis and absorption of this modified form, and subsequent release of the quercetin therein.

Isoquercitrin (IQC) has greater availability but by far the best option is another water-soluble form: enzymatically modified isoquercitrin. Given that water solubility is enhanced by glycosylation (attachment to a sugar), scientists have evaluated the bioavailability of several orally administered quercetin glycosides.

Specification

Function

1.Anti-inflammatory

2.Anti-oxidant,anti-mutagenic 

3.Anti-clastogenic,anti-depressant

4.Hypotensive,hypolipidemic

5.Anti-viral properties